Studies towards the synthesis of hyperireflexolide A

• G. Hari Mangeswara Rao

Beilstein J. Org. Chem. 2018, 14, 2106–2111, doi:10.3762/bjoc.14.185

• G. Hari Mangeswara Rao Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India Department of Chemistry, Texila American University, Georgetown, Guyana 10.3762/bjoc.14.185 Abstract The first approach to hyperireflexolide A, based on the synthesis of γ-lactone-fused

• hyperireflexolide A. Keywords: alkylation; allylation; cross metathesis; hyperireflexolide A; spiroterpene; Introduction Hyperireflexolide A (1) [1] is a spiroterpenoid, isolated from hypericum reflexum, plants of the genus hypericum (Figure 1). Hyperireflexolide A is widely used in folk medicine, displays

• selectivity for the assemblage of various substituents on the convex surface. The lactone part can serve as a useful tool to append various side chains. Results and Discussion The presence of a γ-lactone-fused cyclopentane moiety in hyperireflexolide A (1) attracted our attention. In fact, the ketal moiety in